Inhibitory synaptic transmissions to the bed nucleus of the stria terminalis neurons projecting to the ventral tegmental area are enhanced in rats exposed to chronic mild stress

Abstract The comorbidities of depression and chronic pain have long been recognized in the clinic, and several preclinical studies have demonstrated depression-like behaviors in animal models of chronic pain.These findings suggest a common neuronal basis for depression and chronic pain.Recently, we reported that the mesolimbic dopaminergic system w

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Mutations in Cancer Cause Gain of Cysteine, Histidine, and Tryptophan at the Expense of a Net Loss of Arginine on the Proteome Level

Accumulation of somatic mutations is critical for the transition of a normal cell to become cancerous.Mutations cause amino acid substitutions that change properties of proteins.However, it has not been studied as to what extent the composition and accordingly chemical properties of the cell proteome is altered as a result of the increased mutation

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